The Seasiders drew 1-1 away to big-spending QPR in midweek but only a late equaliser denied them a victory.
Grayson will again be reluctant to alter his starting line-up, meaning Steve Kabba and Ben Burgess will continue in partnership up front against the Bluebirds at Bloomfield Road.
Grayson will assess the fitness of fellow striker Daniel Nardiello, who has struggled with injuries following his summer switch from QPR.
Nardiello could remain sidelined along with midfielder Jermaine Wright and defender Stephen Crainey.
However, Stephen McPhee is edging closer to fitness after a calf injury and could be in contention for a return, while Zesh Rehman is available again after being ineligible in midweek under the terms of his loan agreement from Loftus Road.
Dave Jones is expected to keep faith with his Cardiff side.
The Bluebirds boss watched his charges end a three-match winless streak with Tuesday's 2-1 win over Coventry and he is unlikely to make any changes against the Seasiders.
Striker Jay Bothroyd finally grabbed his first goal for the club at Ninian Park while Ross McCormack netted his sixth of the season from the penalty spot.
Stephen McPhail will continue in midfield, meaning Paul Parry will have to settle for a place on bench, while captain Darren Purse will keep Gabor Gyepes out of the starting XI.
Winger Mark Kennedy could start again after a solid return from his hamstring problem, but the game may come too soon for Riccardo Scimeca (knee) and Tony Capaldi (knee).