Neither player would have been ready for Friday night's game at Brighton, which was postponed because of fog.
But Whittingham (calf) and Peltier (thigh) will be checked as Cardiff seek to avenge their 3-1 Sky Bet Championship defeat at Villa five weeks ago.
Whittingham is celebrating 10 years at CCFC after joing from Villa in January 2007.
Gabon defender Bruno Ecuele Manga could play before leaving for the African Nations Cup.
Villa midfielder Jack Grealish is set to miss out after suffering a dead leg in the 1-1 draw with Leeds.
Grealish was replaced by Ross McCormack on Thursday night, and the Scotland striker will be hoping to return to the starting line-up on his old Cardiff stamping ground.
Jordan Ayew is available as Ghana have granted the midfielder permission to play before he links up for African Nations Cup duty.
But nine-goal top scorer Jonathan Kodjia could miss out with his country, the Ivory Coast, planning a training camp in Paris next week.
MATCH FACTS
- Cardiff have failed to score in three of their last four home league games against Villa, although three of those matches were played in the 1970s.
- Villa have won seven of their last nine league games against the Bluebirds, keeping seven clean sheets in that time.
- Cardiff have kept just one clean sheet in their last 14 home league contests.
- The Villans could win successive away league games for the first time since September 2014.
- Villa won just twice away from home in the league in 2016, with both wins coming under Steve Bruce.
Officials:
Referee: ANDY DAVIES
Assistants: Timothy Wood and Daniel Leach
Fourth Official: Christopher Sargin