Wigan won the cup with a 1 - 0 victory over Man City last season but were also relegated to the Championship.
Wigan progressed to the 5th round by beating Premier League Crystal Palace at the DW Stadium on Saturday.
The full draw is:
Manchester City v Chelsea
Sheffield United or Fulham v Nottingham Forest or Preston North End
Arsenal v Liverpool
Brighton & Hove Albion v Hull City
Cardiff City v Wigan Athletic
Sheffield Wednesday v Charlton Athletic
Sunderland v Southampton
Everton v Swansea City
Fixtures to be played on the weekend on February 15th / 16th.