Central defender Bruno Manga has been advised to take another week's rest while he recovers from a knee injury, while striker Kenwyne Jones misses out with a calf strain and Federico Macheda is continuing his recovery from a back problem.
Jones could be available to face Championship opponents QPR at Loftus Road next Saturday, but Macheda is doubtful for that game and Ben Turner continues to be sidelined following ankle surgery.
Cardiff's opponents are under the direction of two former Bluebirds in manager Neal Ardley and his assistant Neil Cox.
AFC Wimbledon are expected to persevere with their 3-4-3 formation.
Boss Ardley is likely to take the opportunity to give his three-pronged strike force another chance to gel following Saturday's 2-0 defeat by Plymouth.
Tom Elliott, Lyle Taylor and Adebayo Akinfenwa showed promised against the Pilgrims but Ardley wants more from his forward trio if the experiment is to work.
AFC Wimbledon will be hoping for a better Capital One Cup performance than last season when they perished 3-1 at MK Dons in the first round.
Russell Slade (Cardiff City): “Wimbledon know how to put a cup run together. It was only last January they were playing Liverpool at home in the FA Cup and it took two Steven Gerrard goals to put them out.
“They will come with their strongest team and give us a tough match.”
Neal Ardley (AFC Wimbledon): “I have fantastic memories of my time at Cardiff City, both as a player and coach. I have stayed in touch with a lot of friends I made during that time and it will be good to go back.”
The officials:
Referee: BRENDAN MALONE
Assistants: Marvyn Amphlett and Neil Radford
Fourth Official: Richard Martin
MATCH FACTS
- This will be the first-ever competitive meeting between the two clubs.
- AFC Wimbledon have been knocked out of the League Cup at the first-round stage against higher-league opposition in each of the last three seasons.
- Cardiff have only been eliminated in three of their 22 League Cup ties against lower-league opposition since 2002-03.
- The Welsh side have progressed in 11 of their last 12 League Cup ties at home, with their only home defeat coming last season versus Bournemouth.