Fabio Da Silva's red card in the 2-0 midweek loss to Leeds - Cardiff's first defeat at home for 14 league games - and subsequent one-match ban has opened up a vacancy at right-back, which Lee Peltier would be expected to fill.
But Peltier suffered severe bruising to his foot at Bristol City last weekend meaning regular centre-back Matthew Connolly will be moved across the defence.
Central defender Sean Morrison is set to make his first start since suffering knee ligament damage in December, with Bluebirds boss Russell Slade retaining the rest of the side which began against Leeds.
Murphy has not featured in the past two matches because of a calf problem but has returned to training.
Skuse has also stepped up his recovery since being missing from the start of February with a toe ligament injury.
Defender Kevin Foley (ribs) is expected to be available, along with midfielders Kevin Bru and Ben Pringle who both picked up minor knocks in the midweek 2-2 draw at Bolton.
MATCH FACTS
- Cardiff are unbeaten in their last three home games against Ipswich after losing the previous three in a row.
- Ipswich have failed to score in just two of their last 14 league matches with Cardiff, including this season's reverse fixture which ended goalless.
- Only Hull (one) have lost fewer home games than Cardiff this season (two), though one of those two defeats came last time out against Leeds.
- Only Burnley (29) have earned more points away from home in the Championship than Ipswich this season (28).
- Despite their excellent away record, the Tractor Boys have won just one of their last six on the road (D2 L3).