The Dutch winger, who has started in two Carling Cup ties this season, last appeared for the Owls in a league game in April, but is likely to be rewarded for his recent performances off the bench.
Esajas scored in last Friday's derby defeat to Sheffield United and helped transform Brian Laws' side after the break.
Laws is not expected to make any other changes, but Mark Beevers has shaken off a knee injury and is available again and fellow centre-half Richard Wood has recovered from illness and a groin problem.
Frank Simek has made a full recovery from injury and is pushing for a recall, but lacks match fitness so Lewis Buxton is expected to retain his place at full-back.
Marcus Tudgay will partner on-loan Luke Varney up front, with Akpo Sodje, Francis Jeffers and Leon Clarke all expected to start on the bench.
Dave Jones is expected to once again ring personnel and tactical changes for the trip.
The Cardiff manager called upon six new faces for the 1-0 Carling Cup defeat at Aston Villa on Wednesday night - with Peter Enckelman, Adam Matthews, Gabor Gyepes, Tony Capaldi, Riccardo Scimeca and Gavin Rae all starting.
And it remains to be seen how many, if any at all, are included in Jones' starting XI at Hillsborough, the scene of Cardiff's play-off heartache on the final day of last season.
Jones also switched to an unorthodox 4-5-1 formation at Villa Park but is likely to revert to the more familiar 4-4-2 for the club's return to league matters against Brian Laws' Owls.
Midfielder Stephen McPhail misses out as he serves the final game of a three-match suspension for his sending off at Reading.
Ross McCormack (hamstring) and fellow forward Kelvin Etuhu (ankle) will be out for longer than initially expected, with the former hoping to return in mid-October and the latter around the end of November.
Full-back Kevin McNaughton (ankle) is also not quite ready.